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KMID : 0608520070130010161
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Korean Journal of Oriental Medicine
2007 Volume.13 No. 1 p.161 ~ p.164
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Acute Toxicity Study on SsangHwaTang in Mice
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Ma Jin-Yeul
Park Dae-Hun
Park Kyoung-Soo
Do Kyoung-Tag
Shin Hyun-Kyu
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Abstract
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SsangHwaTang has been traditionally prescribed a medicine as a restorative. In this study, We investigated the acute toxicity about water-extracted SsangHwaTang Twenty-five mice completed 14 days of oral SsangHwaTang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000㎎/㎏. And then we observed survival rates, general toxicity, change of body weight, and autopsy. Compared with the control group, we could not find any toxic alteration in all treated groups (2560, 3200, 4000 and 5000㎎/㎏). In conclusion, LD50 of SsangHwaTang was over 5000㎎/㎏ and it is very safe to ICR mice.
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KEYWORD
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SsangHwaTang, Acute toxicity, Safety, LD50
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